Abstract: Organizations worldwide face mounting pressure to address employee wellbeing while maintaining productivity and retention. This article synthesizes evidence from systematic reviews examining organizational-level interventions targeting the psychosocial work environment. Drawing on research covering nearly 1,000 primary intervention studies, we identify intervention approaches with strong-to-moderate evidence of effectiveness, including working time flexibility, employee influence on work organization, comprehensive psychosocial improvements, and burnout reduction programs. While certain interventions demonstrate clear benefits—particularly those enhancing worker control and addressing work-life integration—evidence remains inconclusive for leadership development and stress reduction initiatives. We examine why some interventions succeed while others fail, highlighting the critical roles of implementation quality, contextual factors, and the distinction between proximal (work environment) and distal (health and retention) outcomes. The article concludes with actionable frameworks for practitioners designing evidence-based workplace interventions and identifies priorities for advancing both intervention science and practice.
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